Guiding Stones is an incredibly powerful card in Rex Murphy and Monterey Jack, especially with a full 4 player group. They both can start with Well Connected, then run a resource heavy build. When you're sitting on 40 resources, you're suddenly vacuuming up 6+ clues in an action. Incorporate Alchemical Distillation with an Enlightened Distillate, suddenly you've got a near endless supply of location emptying charges.
I could see a strong build with Eldritch Sophist and investigators with Mystic splash too. Daisy for sure. Or even Ursula, since many relics come with charges that Sophist can move. Looking at the self-replenishing Runic Axe. Gimmicky, but fun!
Keep in mind, this card is most effective in multiplayer, and most often only CRAZY on high-clue low-shroud locations. It's an almost niche specialization, best when there are mountains of clues to tackle.