
I built a Dexter Drake that is a flex fighter, and this card seems invaluable. If you're taking Arcane Research (or two copies of it), In the Thick of It, and maybe even Charon's Obol, Hallowed Chalice looks amazing for survivability (especially if you can tutor 'Charm' with Molly Maxwell). Surprisingly, aside from Sword Cane and upgrading to Cyclopean Hammer late game, Dex's hand slot can be relatively uncontested if you're relying on Arcane slots to do your damage dealing.
Dex is actually the surprise winner of the Scarlet Keys mystic cards suite. Power Word, String of Curses, Uncage Soul (3) all seem pretty powerful with him, and even the Rogue cards such as Kicking the Hornet's Nest, Underworld Market, and Dirty Fighting can find a home with him.