If you manage to get your skill high enough and play this with Snipe it is essentially a guaranteed 2 damage, as the extra action negates the action lost playing Snipe. Bob Jenkins can throw Jury-Rig on it to reach the high numbers necessary to make this happen.
The year is 2077, Arkham Horror is now exclusively playable on expert mode and you're faced with a (7) test threatening to take all your clues or deal up to 7 horror. You are 5 below naturally and have a single Eureka in hand to commit. Your friend commits guts, there's 10 blessed tokens in the bag. Success is within reach as you continue to stack the odds further in your favor. You draw an autofail and go insane.
This is a brutal weakness. With Kate's measly 2, you're already 1 below on this card's base difficulty, and every single use of Kate's ability makes this test worse. Unlike Harvey, you don't even get the benefit of having a threshold of 2 or 3 clues, every single clue on an asset is a risk until you draw this card. It's not unsolvable, but the threat is real and this card can delete Kate from the game if you aren't prepared for it.
With Kate's introduction in Hemlock, we also saw the addition of science cards like Chemistry Set, and extra tools through Dr. Charles West III and Tinker. You're likely going to have a lot of assets out that can have a clue placed on them, and assuming you don't want to forego your investigator's ability, there's a few things that can mitigate this weakness:
Logical Reasoning or its elder sibling Logicaler Reasoning. There aren't very many seeker cards that even mention horror, so there isn't much competition here. Kate has off-class access to First Aid and Delay the Inevitable, but neither is an ideal solution. Moment of Respite is also worth a look.
Stock up on will commits through Guts, Inquiring Mind, and Unexpected Courage. The drawback here is that each will commit you add will lower your deck's overall efficiency. A hand full of will commits before or after this card is drawn are mostly just going to take up space.
"Fool me once..." is an insight, so Kate has access to it. If drawn early you can use this to trap your weakness and mitigate its effect on future cycles. That said, its value depends heavily on how often you cycle and the first test will happen no matter what.
There are 11 Seeker allies with 2 or more sanity to let pay the price of your hubris, and Eldritch Sophist has 3 sanity soak if you're absolutely determined to go that route.
Having said all that, I like this weakness. Kate has the potential for an absurd science toolkit, and this weakness makes it possible to have it all blow up in your face.
TL;DR - Run Carolyn Fern with Kate and turn bad science into good money.
Edit: There's a ruling on Surprising Find that makes this more manageable. "Next test" on Flux Stabilizer counts for the current test, so you can boost will in response to drawing your weakness; however, it will change the test difficulty - so each clue represents +1 will overall. Just don't draw the autofail if you're pumping clues to pass.
Bianca "Die Katz" is a key card for Alessandra Zorzi.
With Fine Clothes you can get an enemy plus a flexible >5 ressources when you need them and then you have an enemy to Power Word with.
Then it gets interesting! Bianca should be immune to most encounter card effects that interact with enemies.
Take Grizzled and choose the keyword "Criminal". It is shared with Zamacona. This might help you to Backstab him.
Pimp Bianca "Die Katz" with Grizzled [Upgrade: Nemesis] to safely reduce the tabooed Words of Power willpower (3) test to zero and make her a reliable call centre for Power Word [Upgrade: Thrice Spoken] that reliably distributes commands to other enemies.
Pimp her even further with Existential Riddle and let her follow you as a aloof assistant that "hunts" you. Or use Gené Beauregard to move her with you after moving, stacking your Fox Mask. Otherwise use Blackmail File which is less action efficient but still lets her follow you.
Use her as a target for a safe Stir the Pot (0) to nuke a bunch of enemies. Maybe trigger "Let God sort them out..." if there were multiple enemies. Do it twice using Eldritch Tongue.
When I first saw this card, I thought "big gun deck". Up until this point, the level 0 ammo refill has been slim. This lets you have 3 ammo on any weapon you want. Ornate Bow (no more reload!), Lightning gun, Old Shotgun or even regular Shotgun are all good picks for this. The fact that it is an accessory slot makes it even better if you need a good ally (one of the weaknesses of venturer). It's even an item, so it can be found in a backpack. It's an asset, so it can be played alongside your weapon with ever vigilant. As a cherry on top, it can be used as supplies! This means you can use it on your flashlight or Fingerprint Kit. It's a very flexible card that a lot of investigators could use for a variety of reasons, but works best with those high XP, low ammo/supply assets.
How would Hatchet interact with Watcher from Another Dimension? If you succeed in your attack, the Watcher gets discarded, but is that considered defeated? If not do you just keep the hatchet as you no longer have something to attach it to? If you fail, it would make sense that the hatchet would be attached to the Watcher, as it is now in play.